Self Quiz Chapter 19: Gene Control in Eukaryotes
1) Which of the following statements concerning proto-oncogenes is FALSE?
a
b
c
d
e
A) They are produced by somatic mutations induced by carcinogenic substances.
B) They are involved in producing proteins for cell adhesion.
C) They are genes that code for proteins involved in cell division.
D) They are similar to oncogenes found in retroviruses.
E) They code for proteins associated with cell growth.
2) All of the following are potential control mechanisms for regulation of gene expression in eukaryotic organisms EXCEPT
a
b
c
d
e
A) transcription.
B) the degradation of mRNA.
C) the lactose operon.
D) gene amplification.
E) the transport of mRNA from the nucleus.
3) If one were to observe the activity of methylated DNA, it would be expected that it would
a
b
c
d
e
A) have turned off or slowed down the process of transcription.
B) be unwinding in preparation for protein synthesis.
C) be replicating.
D) induce protein synthesis by not allowing repressors to bind with it.
E) be very active in translation.
4) Two potential devices that eukaryotic cells use to regulate transcription are DNA and histone .
a
b
c
d
e
A) amplification; methylation
B) acetylation; methylation
C) amplification; acetylation
D) methylation; acetylation
E) methylation; amplification
5) When an advertiser wants to send out an ad, a computer prints an address label for everyone on a mailing list. This can be considered analogous to eukaryotic control of genes. The list might be considered to be the array of genes that need to be turned on. Using that analogy, the mailing labels would be analogous to
a
b
c
d
e
A) introns.
B) transcription factors.
C) enhancer regions.
D) methylated bases.
E) RNA polymerase.
The questions (6+7) below refer to the following terms. Each term may be used once, more than once, or not at all.
A. highly repetitive DNA
B. moderately repetitive DNA
C. unique sequence DNA
D. methylated DNA
E. pseudogenes
6) This is most commonly found in inactivated chromosomal regions.
a
b
c
d
e
7) Control regions such as promoters would fall into which class of DNA?
a
b
c
d
e
8) The processing of the RNA transcript involves
a
b
c
d
e
A) the removal of introns and the splicing together of exons.
B) the attachment of introns to ribosomal RNA.
C) the addition of a guanine cap and a poly (A) tail.
D) the removal of exons and the splicing together of introns.
E) Both A and C are correct.
9) Which of the following is NOT a characteristic of triplet-repeat disorders like Huntington's disease?
a
b
c
d
e
A) The triplet is actually translated.
B) In general, these disorders affect the nervous system.
C) These disorders all tend to exhibit delayed onset; affected individuals do not show symptoms for many years.
D) The resulting protein has a string of adjacent glutamines.
E) The number of repeats tends to correlate with the severity of the disease.
10) The gene that stimulates tumorogenesis in Burkitt's lymphoma is expressed when it is moved to chromosome 14 from chromosome 8. This is an example of gene expression regulated by
a
b
c
d
e
A) gene amplification.
B) point mutations.
C) diffusible factors.
D) steroid hormones.
E) translocation.
11) In which of the following would you expect to find the most methylation of the DNA?
a
b
c
d
e
A) tandem arrays for ribosomal genes
B) pseudogenes
C) Barr bodies
D) transposons
E) globin genes
12) Which of the following is LEAST related to the others?
a
b
c
d
e
A) enhancers
B) activators
C) proximal control elements
D) operators
E) repressors
13) In eukaryotes, what is the active transcription generally associated with?
a
b
c
d
e
A) very tightly packed DNA only
B) euchromatin only
C) both euchromatin and highly methylated DNA
D) heterochromatin only
E) highly methylated DNA only
14) Which of the following is LEAST related to the others?
a
b
c
d
e
A) cyclins
B) proteasomes
C) tumor suppression
D) ubiquitin
E) protein degradatation
15) In a nucleosome, what is the DNA wrapped around?
a
b
c
d
e
A) ribosomes
B) mRNA
C) polymerase molecules
D) nucleolus protein
E) histones